OK Art , you got me curious, so I did a little, maybe unscientific test.
I have been loading 38 Special Wadcutters using ~2.6 grains of 700X. I let the powder level in my 12" powder magazine get down to where it was only 1/2" above the aluminum baffle (way lower than I would normally allow). I dropped 10 charges and weighed them.
2.62, 2.60, 2.64, 2.60, 2.62, 2.60, 2.56, 2.60, 2.62, 2.64 Spread = 0.08 grains, Average = 2.61
Then I filled the powder magazine to the top and did the same thing again.
2.58, 2.54, 2.62, 2.66, 2.56, 2.56, 2.56, 2.62, 2.52, 2.62 Spread = 0.14 grains, Average = 2.58
Now it has been my experience that with a freshly filled powder magazine, it takes a while for the powder to settle and get consistent weights, so just for the heck of it I dropped another 10 charges.
2.60, 2.66, 2.70, 2.70, 2.66, 2.64, 2.62, 2.68, 2.66, 2.70 Spread = 0.10 grains Average = 2.664
So I guess you are right Art, there is a difference, and a full powder magazine seems to give slightly higher drop weights.